摘要
目的:观察头孢米诺钠与不同厂家生产的果糖注射液配伍稳定性并进行分析。方法:以273nm为测定波长、293nm为参比波长,ΔA=A273nm-A293nm进行头孢米诺钠定量;测定在25℃、37℃温度下24 h内头孢米诺钠的含量及pH值,观察头孢米诺钠在不同厂家生产的果糖注射液中的物理变化。结果:头孢米诺钠的浓度在15~50mg·L^-1的范围内有良好线性关系(r=0.999 8),温室下头孢米诺钠与不同厂家生产的果糖注射液配伍在4h内均较稳定,其含量均在99%以上,24h时,头孢米诺钠在果糖注射液中不稳定,其含量均低于90%;配伍好的注射液应在4h内滴毕。结论:含量测定方法简便、准确、可靠;同一种药物在不同厂家生产的同种输液液体中配伍,其稳定性也有较大差异。
OBJECTIVE:To evaluate the stability of cefminox sodium in fructose injections from different manufacturers.METHODS:The quantitative test of cefminox sodium was performed under a detection wavelength of 273nm,with reference wavelength of 293nm and ΔA=A273nm-A293nm.The content and pH value of cefminox sodium within 24h was determined at 25℃ and 37℃,respectively to observe its physical change.RESUTLS:The linear range of cefminox sodium was 15~50mg/L^-1 (r= 0.999 8).Under room temperature within 4h,cefminox sodium was stable in fructose injections from different manufacturers with contents all maintained at above 99%.At 24h,cefminox sodium was unstable in fructose injections with content lower than 99% in all the fructose injections.Cefminox sodium should be used up within 4h after mixing with fructose injections.CONCLUSION:The determination method is simple,accurate and reliable.The stability of cefminox sodium varied greatly in fructose injections from different manufactures.
出处
《中国医院用药评价与分析》
2008年第2期131-132,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
头孢米诺钠
不同厂家生产的果糖注射液
配伍稳定性
Cefminox sodium
Fructose injection from different manufacturers
Compatible stability