硝苯地平贴片对自发性高血压大鼠血压的作用

Effects of Nifedipine Adhesive Path on Blood Pressure and Heart Rate in Spontaneously Hypertensive Rats

以硝本地平片（Ⅱ）为对照，研究了硝苯地平贴片（Ⅰ）对自发性高血压大鼠（SHR）的降压作用。结果表明．Ⅰ（40mg／kg、20mg／kg、10mg／kg，皮肤给药）能显著降低SHR的收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP），作用强度与剂量呈正相关．高剂量（40mg／kg）皮肤给药60min后，SBPDBP、MAP分别降低14．80％、16．64％和15．99％，至240min时，SBP、DBP、MAP分别降低了32．47％、41．29％和35．02％．中剂量（20mg／kg）、低剂量（10mg／kg）皮肤给药后亦有显著的降压作用，但降压幅度低于高剂量组。贴片对心率（HR）的影响比片剂组小，与给药前相比，贴片组动物HR在给药120min后有显著降低（P＜0．05，P＜0．01）。Ⅰ作用强度比Ⅱ（10mg／kg，十二指肠给药）弱，但作用较为平稳。Ⅰ和Ⅱ用药后动物心电除P－P间期有不同程度延长外，无其它明显变化。

Effects of nifedipine adhesive patch (1) and nifedipie. tablet(Ⅱ) on blood pressure and heart rate were studied in,pontaneously hypertensive rats (SHR). The results showed that administration of I (40, 21, 10mg/kg, by derma) caused a significynt decrease in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arteria pressure (MAP) with good dose-dependent relationship. At 60 min and 240 min after administration of I (40 mg/kg),SBP, DBP and MAP decreased about 14.80K, 16.64W, 15.99W and 32.47%, 41.29%,35.02% respectively. Thc untihypertensive effects of I (20, 10 mg/kg) were weaker than that of I (40 mg/kg), but were also obvious. The hypotensive cffects of I were weaker and steadier than that of Ⅱ (10 mg/kg, by duodenum). In addition,I exerted smaller influenca upon HR than Ⅱ did. No markedly changes except for longer P-P intorval in electrocardiograph were found after either I or Ⅱ was given.