二阶导数光谱法测定酮洛芬体外经皮渗透量

DETERMINATION OF PERMEATION OF KETOPROFEN ACROSS THE SKIN IN VITRO BY SECOND ORDER DERIVATIVE SPECTROPHOTOMETRY

为进一步探讨酮洛芬透皮给药的可行性，用二阶导数光谱法测定酮洛芬体外经皮渗透量。结果表明，本法可排除皮下组织的干扰，能准确测定药物体外渗透量，且操作简便、快速。平均回收率为９９．００％±１．５１％。

A second order derivative spectrophotometric method was developed for the permeative determination of ketoprofen in vitro . The method can avoid the disturbance of skin tissue. The procedure is simple and rapid. The results are accurate. The mean recovery of ketoprofen is 99.00% ±1.51%.