妊娠期肝内胆汁淤积症患者血脂水平与新生儿血气分析值的相关性分析

Association of Serum Lipid Levels and Umbilical Cord Arterial Blood Gas Analysis in Pregnant Patients with Intrahepatic Cholestasis

目的:探讨妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)患者血脂水平与围生儿预后的关系。方法:选择ICP晚期妊娠60例,正常晚期妊娠25例,测定母体血总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)浓度及围生儿出生即刻脐动脉血气分析值[pH值、血氧分压(PO2)、二氧化碳分压(PCO2)],并进行相关性分析。结果:ICP孕妇血TC、TG、LDL值明显升高,HDL值明显降低,ICP孕妇TC、TG、LDL值与PCO2呈正相关,与pH值及PO2呈负相关,HDL值与pH值及PO2呈正相关,与PCO2呈负相关。结论:ICP孕妇血脂水平与围生儿预后具有相关性,血脂检测应列为ICP的常规。

Objective：To investigate serum lipid levels of pregnant patients with intrahepatic cholestasis, and relationship between prognosis of fetus. Methods： The concentration of serum total cholesterol （TC）, triacylglyceroI （TG）, high density Iipo- protein （HDI.）,low density Iipoprotein （LDL） were measured in 60 cases of ICP and 25 cases of normal pregnant women. PO2, pH and PCO2 of umbilical cord arterial blood had been measured at the time before respiratory of fetus began during cesarean section. Then the relationship between serum Iopid levels and fetus prognosis index were analyzed. Results： The concentration of serum TC.TG, LDL. in serum from patients with ICP were higer than those in normals. While the concentration of HDL was lower than that in normals. In ICP cases, there were significant positive correlations between maternal serum TC, TG, HDL levels and PCO2, whereas there were significant negative correlations between meternaI serum lipid levels and PH, PO2 of umbilical cord arterial blood. Conclusion： Serum lipid levels of patients with ICP are related to the prognosis of perinataI newborn, serum lipid should be routinely detected in patients with ICP.