乙肝免疫球蛋白阻断母婴乙肝病毒传播效果分析

Evaluation on protective efficacy of hepatitis B Immune globulin in preventing mother-to-infant transmission of hepatitis B virus

目的 评价乙肝免疫球蛋白阻断乙肝母婴传播的效果。方法 2004年1月～2007年1月选择梅州城区HBsAg阳性孕期从未注射乙肝免疫球蛋白（HBIG）的孕妇所生的婴儿168例，116例婴儿为观察组，注射乙肝免疫球蛋白联合10μg乙肝疫苗；52例婴儿为对照组，常规接种5μg乙肝疫苗。在12个月龄时进行乙肝病毒血清学检测。结果观察组婴儿HBsAg阳性控制率（94．83％）明显高于对照组（67．31％），无效率（5．17％）明显低于对照组（32．69％），两组的差异有显著性意义（P〈0．01）。结论 乙肝免疫球蛋白阻断母婴乙型肝炎病毒的传播具有显著效果。

Objective To evaluate the protective efficacy in preventing mother-toinfant transmission of Hepatitis B Virus （HBV） of Hepatitis B immune globulin （HBIG） Methods We selected 168 cases infants whose HBsAg positive mothers had never HBIG inoculated during： pregnancy between January 2004 to January 2007,116 cases were observer group, inoculated by HBIG combine 10 μg Hepatitis B vaccine （Hep B）.52 cases were control group, inoculated by 5 μg Hep B singte. Blood serum was collected and HBV markers was tested at 12-month-old. Results In observer group, the HBsAg positive rate was 5.17% and the protective rate was 94.83%. In Control group, the HBsAg positive rate was 32,69% and the protective rate was 67.37%. There was significant difference between two groups （P〈0. 01）.Conclusions The protective efficacy in preventing mother-toinfant transmission of HBIG was significant.