摘要
目的探讨血红素氧合酶-1(Heme oxygennase-1,HO-1)在妊娠期高血压疾病子痫前期中的表达和作用机制。方法选取2002年6月—2005年6月,在甘肃省妇幼保健院及兰州大学第一医院住院的孕妇,其中子痫前期患者56例作为研究组,轻、重度子痫前期患者分别为30例和26例。另选50例同期住院的正常晚孕妇女作为对照组。分别对2组孕妇血清及胎盘溶浆中的HO-1活性进行测定。结果子痫前期组血中HO-1活性与对照组比较显著降低(P<0.05)。其中,轻度子痫前期患者的HO-1含量的降低与对照组比较差异无显著性(P>0.05),而重度则有显著性差异(P<0.05)。胎盘溶浆中HO-1的变化趋势与血中测定一致。结论血清和胎盘溶浆中HO-1的活性变化与子痫前期的病情发展有关,可作为病情变化发展的指标之一。
OBJECTIVE To explore the expression and pathogenic mechanism of heme oxygenase-1 in pregnancy with preeclampsia. METHODS Patients with preeclampsia were matched with normal term singleton pregnant women. The level of HO-1 activity in serum and placenta tissue were compared with each other. RESULTS The activity of HO-1 in patients with preeclampsia＇s serum and placenta homogenate were compared with the control group, both of the HO-1 were significantly decreased compared with the control group（P〈 0.05）, especially in severe PIH（P〉0.05）, hut no significant difference in mild PIH（P〈0.05）. CONCLUSIONS The low activity of HO-1 suggested that it may act a marker of the dysfunction of vascular and placenta cell.
出处
《中国初级卫生保健》
2008年第3期42-43,共2页
Chinese Primary Health Care
