7-苄基-喜树碱的合成研究
Study on synthesis of 7-benzyl-camptothecin
摘要
以20(S)-喜树碱和苯甲醛为起始原料,经Minisci自由基反应和Clemmensen还原反应得到标题化合物,总收率为49.5%。产物结构经MS、1HNMR和IR确证。
7-Benzyl-camptothecin was synthesized from benzaldehyde and 20（ S）-camptothecin via the Minisci radical displacement reaction and the Clemmensen reduction reaction .The overall yield of 7-benzyl-camptothecin was 49.5 %. The structure of the said product was confirmed by IR,MS and IHNMR.
出处
《化学试剂》
CAS
CSCD
北大核心
2008年第2期141-142,144,共3页
Chemical Reagents
基金
江西省科技厅攻关项目(赣财教[2005]132号)
参考文献8
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