摘要
改进了标题化合物的合成工艺。以4-吡啶甲酸乙酯和溴乙酸乙酯为起始原料,经亲核加成、还原、解盐、Dieckmann缩合、成盐制得标题化合物,总收率为54.5%,其结构经IR、13CNMR和1HNMR确证。改进后的工艺操作相对简单,易于工业化生产。
This article refers to the improved method for the preparation of 3-quinuclidone hydrochloride. 3-Quinuclidone hydrochloride was synthesized from ethyl isonicotinate and ethyl bromoacetate as starting materials via the nucleophilic addition, followed by reduction, neutralization, the Dieckmann condensation, and salification. The structure of the target compound was confirmed by IR, ^1HNMR and ^13CNMR, and the overall yield reached 54.5 % . The process was simplified by modifying the reaction conditions and was suitable for manufacturing in commercial scale.
出处
《化学试剂》
CAS
CSCD
北大核心
2008年第2期145-146,共2页
Chemical Reagents
关键词
3-奎宁酮盐酸盐
合成工艺
改进
3-quinuclidone hydrochloride
synthetic process
improvement
