急性缺血性脑血管病患者P-选择素检测及意义

Clinical significance and detection of P-selectin in patients with acute ischemic cerebrovascular disease

目的探索P-选择素在急性缺血性脑血管病发病中的意义。方法选择急性脑梗死患者28例,短暂性脑缺血发作(TIA)患者21例,正常对照30例,检测血小板膜P-选择素和血浆中可溶性P-选择素的含量。结果与正常对照组比较,急性缺血性脑血管病患者血小板膜P-选择素表达明显上调,以急性脑梗死为著;急性脑梗死患者可溶性P-选择素明显升高,TIA患者升高不明显。结论血小板膜P-选择素和血浆中可溶性P-选择素水平可作为评价急性缺血性脑血管病严重程度的生物学指标。

Objective To investigate the clinical significance of detection of P- selectin in patients with acute ischemic cerebrovascular disease. Methods P- selectin on the membrane of platelet and soluble P-selectin in plasma were detected in 28 eases with acute cerebral infarction, 21 eases with transient isebemie attack and 30 controls. Results The level of P- selectin on the membrane of platelet in acute iscbemic cerebrovascular disease was significantly higher than in controls. Especially it was the highest in acute cerebral infarction. The level of soluble P-selectin in plasma was significantly higher in acute cerebral infarction. It was not obviously higher in TIA than in controls. Conclusions The level of P- selectin on the membrane of platelet and soluble P-selectin in plasma may become an important biological marker to evaluate the severity and prognosis of acute ischemic cerebrovascular disease.