血脂、纤维蛋白原与脑梗死患者颈动脉粥样硬化的相关性研究

Dependability research on blood fat, fibrinogen and carotis atherosclerosis in patients with cerebral infarction

目的探讨脑梗死患者颈动脉粥样硬化程度与血脂、纤维蛋白原的关系。方法将脑梗死患者按颈动脉硬化程度分为内膜增厚组、斑块形成组和管腔狭窄组,分别测定总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(apoA)、载脂蛋白B(apoB)、脂蛋白(a)[Lp(a)]、纤维蛋白原(FIB)浓度,分析颈动脉粥样硬化程度与血脂、FIB的关系。结果斑块形成组和管腔狭窄组TG、LDL-C、apoB、FIB浓度显著高于内膜增厚组和对照组,内膜增厚组TG、LDL-C、apoB、FIB浓度显著高于对照组(P均<0.05)。Logistic多元回归分析显示,颈动脉粥样硬化程度与LDL-C、Lp(a)、FIB呈显著正相关(P<0.05,0.01)。结论LDL-C、Lp(a)、FIB是颈动脉粥样硬化的独立危险因素,及时检测脑梗死患者的血脂、FIB和颈动脉粥样硬化情况,对疾病的早期防治具有重要价值。

Objective To research the relationship among blood-lipid, fibfinogen and the degree of carotid artery atheroscleresis in patients with cerebral infarction. Methods Patients with cerebral infarction were divided into intimamedia thickness group, plaque development group and vessel stenesis group. Concentration of cholesterol（ TC）, tfiglyeerides （ TG）, high density lipoprotein cholesterol （ HDL-C ）, low density lipoprotein cholesterol （ LDL-C ）, apolipoprotein A （ apoA）, apolipoprotein B（ apoB）, lipoprotein-a[ Lp（a）], fibrinogen（FIB） were measured. The relationship between the degree of carotid artery atherosclerosis and blood-lipid, fibfinogen was analyzed. Results The concentration of TG, LDL- C, ApoB, FIB in plaque development group and vessel stenosis group were higher than that of intima-media thickness group and control group（ P 〈 0.05 ）. Logistic multiple regression analysis showed that the degree of earotis artheroseleresis had positive correlation with LDL-C, Lp（a） and FIB（P〈0.05,0.01）. Conclusion LDL-C, Lp（a） and FIB are the independent risk factors, detecting blood fat, FIB and observing the information in cerebral infarction patients promptly are of important value in clinical prevention and cure.