原核生物mRNA稳定性的分子机制

Stability of mRNA in protokaryote

原核生物ｍＲＮＡ稳定性的分子机制钟珍萍＊（中国科学院发育所，北京１０００８０）原核生物通过快速繁殖来适应生存，这决定了其ｍＲＮＡ稳定性通常远远次于真核基因ｍＲＮＡ，半衰期仅０．５—５０ｍｉｎ。细胞如何在这么短时间内迅速降解大量的ｍＲＮＡ分子呢？通过哪...

Stability of mRNA in prokaryote is affected by mRNA sequence, nucleases, ribosomes and mRNA binding proteins. Stem loop structure, AUUUA sequence and poly(A) tail regulate the stability of mRNA. Many kinds of nucleases, including RNase E, RNase K, RNase Ⅲ etc,also participate in reducing mRNA's life, but their acting mechanisms are different. Researchers suppose that mRNAbinding proteins in prokaryote regulate mRNA's stability. Ribosomes are generally believed to protect mRNA and retard its decomposition. In the end of this paper, we list some methods which used to frequently study the stability of mRNA.