NO-样松弛因子对止血带休克大鼠血管舒缩活动的影响

THE EFFECT OF NO LIKE RELAXING FACTOR ON VASCULAR REACTIVITY IN TOURNIQUET SHOCK RAT

本工作在大鼠止血带休克（ＴｏＳ）模型上观察ＮＯ前体Ｌ－精氨酸Ｌ－Ａｒｇ，ＮＯ合成阻断剂Ｌ－ＮＮＡ及可溶性鸟苷酸环化酶抑制剂亚甲兰（ＭＢ）对离体胸主动脉舒缩活动的影响。发现止血带休克大鼠离体灌流的主动脉对去甲肾上腺素的反应性降低。血管组织ｃＧＭＰ含量增加。Ｌ－Ａｒｇ可增强这一变化，而Ｌ－ＮＮＡ或ＭＢ可减轻上述变化，而且这些药物作用不受血管内皮是否存在的影响。实验结果提示。

This work was done on rat tourniquet shock(ToS) model. It was found that reactivity of isolated perfused aortic ring to noradrenaline decreased, while cGMP content of the aortic tissue increased. These changes could be potentiated by perfusion with L arginine (NO precursor). On the other side, when the aortic ring was perfused with L NNA (NO synthesis inhibitor) or methylene blue (soluble cGMPase inhibitor), the changes could be attenuated. The effect of these drugs are independent of the presence of vascular endothelium. The results suggest that non endothelium derived NO like relaxing factor may be one of the factors causing low vascular reactivity of the ToS animals.