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尼唑苯酮的合成 被引量：2

Synthesis of Nizofenone
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摘要 以苄基咪唑为原料制得二乙氨基甲基咪唑,再与2,2'-氯-5-硝基二苯酮缩合得产品尼唑苯酮。收率71.3%,产品含量99.0%,是一条有望工业化的合成路线。 A practical synthesis method of nizofenone was studied. Nizofenone was synthesized from 1-benzyl-imidazole to give 1-benzyl-2-diethylaminomethyl-imidazole. 1-benzyl-2-diethylaminomethyl-imidazole reacted with 2,2＇-chloro- 5-nitro-dibenzone to give the target product with the corresponding overall yield and purity of 71.3% and 99.0%.
作者 郑正春 童志杰
机构地区 湖南医药工业研究所
出处 《精细化工中间体》 CAS 2008年第1期27-28,共2页 Fine Chemical Intermediates
关键词 尼唑苯酮 苄基咪唑 合成 nizofenone 1-benzyl-Imidazole synthesis
分类号 O625.632 [理学—有机化学]
  • 相关文献

参考文献5

  • 1Nakanishi, Yokobe M, Arai T, et al. 1-[2-(2-Chlorobenzoyl) -4-nitrophenyl ]-2- (diethylaminomethyl)-imidazole [P]. US : 3 915 981, 1975-10-28.
  • 2Yasuda H. Antianoxic effect in animal models [J ]. Pharmacodyn, 1978, 233: 136.
  • 3Saito I. Multicenter clinical studies[J]. Neurol.res., 1983, 5: 29.
  • 4Ohta T.Multicenterclinicalstudies[J].Neurosurg, 1986, 64: 420.
  • 5Horizoe H. Toxicity studies[J]. Oyo Yakuri, 1985, 30: 627.

同被引文献12

  • 1Michio N,Tetsuo Y,Tomio A,et al. 1-F(2-Chlorobenzoyl)-4-nitrophenyl]-2-(diethylamino- methyl)-imidazole:US, 3915981 [P]. 1975-10-28.
  • 2Bastiaansen L A M, Van Lier P M, Godefroi E F. Imidazole-2-carboxaldehyde[J]. Organic Syntheses, 1981,60: 72-74.
  • 3Martinez J M L, Romasanta P N, Chattah A K, et al. NMR characterization of hydrate and aldehyde forms of imidazole-2-carbo- xaldehyde and eerivatives[J]. Organic Chemistry, 2010, 75: 3208-3213.
  • 4Ochiai C, Asano T, Takakura K, et al. Mechanisms of cerebral protection by pentobarbital and nizofenone correlated with the course of local cerebral bloodflow changes[J]. Strokel, 1982,3:788 -796.
  • 5Yasuda H. Antianoxic effect in animalmodels [J]. Phamacodyn, 1978, 233 : 136.
  • 6Saito I. Multieenterclinical studies[ J]. Neurolres, 1983,5:29.
  • 7OhtaT. Multicenterclinical studies[ J]. Neurolres, 1986,64:430.
  • 8Hoizone H. Toxicity studies [ J ]. Oyo Yakuri, 1985,30:627.
  • 9MichioN,TetsuoY. 1 - [ 2 - ( 2 - chlorbenzoyl ) - 4 - nitrophenyl ] - 2 - (diethylaminomethyl) - imidazole: US, 3915981 [ P]. 1975 - 10 - 28.
  • 10Martinez J M L,Romasanta P N,Chattah A K, et al. NMR characteriza- tion of hydrate and aldehyde forms of imidazole - 2 - carboxaldehyde and eerivative [ J ]. Organic Chemistry, 2010,75 : 3208 - 3213.

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精细化工中间体
2008年 第1期

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