摘要
在头孢酸合成生产中,借助原料分析,采用了高效液相法测定反应原料残余量的方法,对生产中影响收率的关键工序进行工艺优化。优化工艺条件为:n(AE-活性酯)∶n(7-氨基头胞烷酸)、反应温度15～25℃、反应时间1h、原料的残留浓度1.60%以下,此条件下产品收率提高至90%以上,并且每批产量均比较稳定。
The key procedures influencing the reaction yield were optimized in the reaction courses of cephalosporin through the analysis of material using HPLC, optimal reactive conditions were obtained as follows： n （AE-ester） ： n （7- aminocephalosporanic acid）=l ： 1-1.2, reacting temperature 15-25℃, reacting time 1 h, and the lower reaction material remaining（1.60%）. The reaction yield increases to over 90%, and was stable in each production.
出处
《精细化工中间体》
CAS
2008年第1期31-33,共3页
Fine Chemical Intermediates
关键词
头孢中间体
合成
工艺
研究
cephalosporin intermediate
synthesis
technology
reserach
