1Biedler JL, Richm H. Cellar resistance to actionmycin D in Chinese hamster ceils in vitro:cross-resistance, rafiautographic studies[J]. Cancer Res, 1970,30(4) : 1174.
2Ling V, Thompson L. Reduced permeability in CHO cells as a mechanism of resistance to colchicine[J]. J Cell Physiol, 1974,83 : 103.
3Katner N,Riodan JK , Ling V. Detection of polycoprotein in multidrug resistant cell lines by monoclonal antibodies [J]. Nature, 1983,211: 1285.
4Takara K,Sakaeda T,Okumura K. An update on overcoming MDRl-mediated multidrug resistance in cancerchemotherapy[J]. Curr Pharm Des, 2006,12 (3) : 273.
6Almquist KC, Loe DW, Hipfner DR, et al. Characterization of the Mr 190000 multidrug resistance protein (MRP) in drug selected and transfected human tumor cells[J]. Cancer Res, 1995,55 : 102.
7Marquardt D,Center MS. Involvement of vacuolar H (+)-a-denosine triphosphatase activity in multidrug resistance in HL60 cells[J]. J Natl Cancer Inst, 1991,83 : 1098.
10Doyle LA, Yang W, Abruzzo LV, et al. A multidrug resistance transporter from human MCF-7 breast cancer cells[J]. Proc Natl Acad Sci USA, 1998,95 (26) : 15665.
2Gottesman MM, Pastan L, Ambudkar SV. P-gly-coprotein and multidrug resistance[J]. Curr OpinGenet Dev, 1996,6(5):610
3Donna M, Bradshaw, Robert J, et al. Clinicalrelevance of transmembrane drug as a mecha-nism of multidrug resistance [J]. Journal ofClinical Oncology, 1998,16(11): 3674
4Mukhtar H, Ahmad N. Tea polyphenols: pre-vention of cancer and optimizing health[J]. AmJ Clin Nutr, 2000, 71(6 Suppl):1698S
5Yang CS, Chung JY, Yang G, et al. Tea andtea polyphenols in cancer prevention[J]. J Nutr,2000,130(2S Suppl):472S
6Jacques F. Analysis of the tangled relationshipsbetween P-glycoprotein-mediated multidrug re-sistance and the lipid phase of cell membrane[J]. Eur J Biochem, 2000,267(2):277
7Lau A, Mightingale S, Taylor GP, et al. En-hanced MDR1 gene expression in human T-cellleukemia virus-I-infected patients offers newprospects for therapy[J]. Blood, 1998,91(7):2467
8Wood L, Palmer M, Hewitt J, et al. Results of aphase Ⅲ, double-blind, placebo-controlled trialof megestrol acetate modulation of P-glycopro-tein-mediated drug resistance in the first-linemanagement of small-cell lung carcinoma[J]. BrJ Cancer, 1998,77(4):627
9Liwu Fu,Yongju Liang,Liwen Deng,Yan Ding,Liming Chen,Yanli Ye,Xiaoping Yang,Qichao Pan.Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance[J].Cancer Chemotherapy and Pharmacology.2004(4)
10Lia van Zuylen,Kees Nooter,Alex Sparreboom,Jaap Verweij.Development of Multidrug-Resistance Convertors: Sense or Nonsense?[J].Investigational New Drugs.2000(3)
3Takara K, Sakaeda T, Okamura K. An update on overcoming MDR1-mediated multidrug resistance in cancer chemotherapy[J]. Curr Pharm Des, 2006,12 (3) : 273.
4Marzolini C, Paus E, Bucin T, et al. Polymorphisms in hunman MDR1 (P-glycoproteim) :recent advances and clinical relevance[J]. Clin Pharmacol Ther, 2004,75 ( 1 ) : 13.
5Liu Y, Lillehei K, Cobb WN, et al. Overcoming MDR by ultrasound-induced hyperthermia and P -glycoprotein modulation[J]. Biochem Biophys Res Commun, 2001,289 ( 1 ) : 62.
6Stein U,Jurchott K,Walther W, et al. Hypermia-indueed nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters[J]. J Biol Chem,2001,276(30) :28562.
7Vilaboa NE,Galan A, Troyano A, et al. Regulation of multidrug resistance 1 (MDR1)/P- glyeoprotein gene expression and activity by heat -shock transcription factor1 (HSF1)[J]. J Biol Chem,2000,275(32) : 24970.
8Wanebo HJ,Kennedy BJ,Chmiel J,et al.Cancer of the stomach.A patient case study by the America colledge of surgeons[J].Ann Surg,1993,218:583-592.
9Hanazaki K,Mochizuki Y,Kachida T,et al.Post-operative chemotherapy in non-curative gastrectomy for advanced gastric cancer[J].Hepatogastoenterology,1999,46(26):1238-1243.
10Chun JH,Kim HK,Lee JS,et al.Weekly irinotecan in patients with metastatic gastric cancer failing cisplatin-based chemotherapy[J].Jpn J Clin Oncol,2004,34(1):8-13.
