延髓面神经后核内侧区呼吸相关神经元的放电形式

DISCHARGE PATTERNS OF RESPIRATORY RELATED NEURONES IN THE MEDIAL AREAS OF NUCLEUS RETROFACIALIS OF MEDULLA

实验用家兔和SD大鼠，氨基甲酸乙酯麻醉（1g／kg，ivorip）。记录隔神经或隔肌放电作为呼吸的指标。在延髓面神经后核内侧区（mNRF）细胞外记录呼吸相关神经元（RRNs）放电，在家兔所记录到的249个RRNs中，吸气神经元118个（47．4％，可分4种亚型），呼气神经元91个（36．5％，包括4种亚型），呼吸跨时相神经元40个（16．1％，包括E－I和I－E）。在大鼠所记录到的153个RRNs中，吸气神经元68个（44.5％），呼气神经元55个（35．9／），呼吸跨时相神经元30个（19．6％），在mNRF分布有较多的呼气-吸气跨时相神经元（E－IPS），这类神经元放电总是先于隔神经吸气性放电，可能在基本呼吸节律发生中起重要作用。

Experiments were performed on rabbits and SD rats, both anesthetized with urethane (1. 0 g/kg, iv or ip). Discharges of phrenic nerve and the diaphragmatic muscle electric activities were monitored. Discharge patterns of the respiration-related neurons (RRNs) in the medial area of nucleus retrofacialis (mNRF) were recorded and analyzed. Among the 249 RRNs recorded in the mNRF of the rabbits, 118 were inspiratory(I, 47. 4%), 91 expiratory (E, 36. 5% ), and 40 phase-spanning (PS, 16. 1 %).Both I and E neurons could be further subdivided into 4 subtypes, the PS neurons intoE-I and I-E type. In the 153 RRNs recorded in rats, 68 were I (44. 5%), 55 E(35. 9 % ), 30 PS (19. 6 % ). It was found that a group of E-I PS neurons that fire preceding phrenic nerve respiratory activity are located in the mNRF, which was believedto be important in the generation of the basic respiratory rhythm.