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生物分子溶液中的弱相互作用研究进展 被引量：5

Research Progress on the Weak Interactions of Biomolecules in Solution
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摘要 弱相互作用是生物分子体系中普遍存在的一类重要作用,在分子组装和分子识别以及研究结构-功能-活性关系等方面有着极其重要的作用,一直是科学研究的前沿.本文从生物分子内弱相互作用的分类和研究方法方面,针对国内国际研究的前沿和热点以及笔者自身的科研成果,揭示了生物分子溶液内部弱相互作用的特点及其多元的研究手段. Weak interaction plays an essential role in the structures and properties of proteins and nucleic acids as well as in the behavior of many biological systems. In the present paper, the research progress is summed up according to the hot research work in recent years. The different type and the various research methods are introduced to reveal the features of weak interactions in biological systems.
作者 张荣 罗三来 郑敦胜
机构地区 广东药学院药科学院物理化学教研室
出处 《化学研究》 CAS 2008年第1期102-105,111,共5页 Chemical Research
基金 广东省自然科学基金博士科研启动基金(07301567) 广东药学院人才引进科研启动基金(2006YKX05)资助项目
关键词 生物分子体系 溶液 弱相互作用 研究疗法 综述 biological systems solution weak interactions research method review
分类号 O641 [理学—物理化学]
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参考文献26

  • 1Desfrancois C, Caries S, Schermann J P. Weakly bound clusters of biological interest [ J], Chem Rev, 2000, 100( 11 ) : 3943 - 3962.
  • 2Takamuku T, Matsuo D, Tabata M. et al. Structure of aqueous mixtures of N,N-dimethylacetamide studied by infrared spectroscopy, X-ray diffraction, and mass spectrometry [ J]. J Phys Chem B, 2003, 107 (25) : 6070 - 6078.
  • 3Dyson H J, Wright P E. Unfolded proteins and protein folding studied by NMR [J]. Chem Rev, 2004, 104(8) : 3607 -3622.
  • 4Bene J E D, Jordan M J T. Vibrational spectroscopic and NMR properties of hydrogen-bonded complexes: Do they tell us the same thing? [J]. J Am Chem Soc, 2000, 122(19) : 4794 -4797.
  • 5Sieler G, Schweitzer-Stenner R, Holtz J S W, et al. Different conformers and protonation states of dipeptides probed by polarized Raman, UV-resonance Raman, and FTIR spectroscopy [ J ]. J Phys Chem B, 1999, 103 (2) : 372 - 384.
  • 6Lee K-H, Benson D R, Kuczera K. Transitions from α to π helix ohserved in molecular dynamics simulations of synthetic peptides[J]. Biochem, 2000, 39(45) : 13737 - 13747.
  • 7Lampela O, Juffer A H, Rauk A. Conformational analysis of glutathione in aqueous solution with molecular dynamics [J]. J Phy Chem A, 2003, 107 (43) : 9208 - 9220.
  • 8Vamai P, Lavery R. Base flipping in DNA: Pathways and energetics studied with molecular dynamic simulations [ J]. J Am Chem Soc, 2002, 124 (25) : 7272 - 7273.
  • 9Pitera J W, Gunsteren W F. The importance of solute-solvent Van der Waals interactions with interior atoms of biopolymers [J]. JAm Chem Soc, 2001 , 123(13) : 3163 -3164.
  • 10Gellman S H, Dado G P, Liang G B, et al. Conformation-dlreeting effects of a single intramolecular amide-amide hydrogen bond: Variable-temperature NMR and IR studies on a homologous diamide series [J]. J Am Chem Soc, 1991, 113(4) : 1164 - 1173.

二级参考文献14

  • 1Shen,L.L.; Pernet,A.G.Proc.Natl.Acad.Sci.U.S.A.1985,82,307.
  • 2Shen,L.L.; Baranowski,J.; Pernet,A.G.Biochemistry 1989,28,3879.
  • 3Shen,L.L.; Mitscher,L.A.; Sharma,P.N.; O'Donnell,T.J.; Chu,D.W.T.; Copper,C.S.; Rosen,T.; Pernet,A.G.Biochemistry 1989,28,3886.
  • 4Hanessian,S.; Saladino,R.; Nunez,J.C.Bioorg.Med.Chem.Lett.1996,6,2333.
  • 5Palǜ G.; Valisena,S.; Ciarrocchi,G.; Gatto,B.; Palumbo,M.Proc.Natl.Acad.Sci.U.S.A.1992,89,9671.
  • 6Fan,J.Y.; Sun,D.; Yu,H.; Kerwin,S.M.; Hurley,L.H.J.Med.Chem.1995,38,408.
  • 7Sissi,C.; Andreolli,M.; Cecchetti,V.; Fravolini,A.; Gatto,B.; Palumbo,M.Bioorg.Med.Chem.1998,6,1555.
  • 8Noble,C.G.; Barnard,F.M.; Maxwell,A.Antimicrob.Agents Chemother.2003,47,854.
  • 9Son,G.S.; Yeo,J.A.; Kim,M.S.; Kim,S.K.; Holmén,A.;Akerman,B.; Nordén,B.J.Am.Chem.Soc.1998,120,6451.
  • 10Bailly,C.; Colson,P.; Houssier,C.Biochem.Biophys.Res.Commun.1998,243,844.

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化学研究
2008年 第1期

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