新发高血压患者初始降压药物依从性调查

STUDY ON THE COMPLIANCE OF PATIENTS WITH NEWLY DIAGNOSED HYPERTENSION ON ANTIHYPERTENSIVE DRUGS

[目的]观察新发高血压患者服用降压药物的依从性和影响药物依从性的因素。[方法]985例初次诊断为高血压病的轻、中度高血压患者,在5大类降压药物的基础上根据每个患者的具体情况进行了处方的优选,观察8周,根据血压达标情况和药物不良反应调整降压药物,比较服药8周后不同药物的依从性。[结果]观察结束时料5类降压药物中依从性高低依次为利尿剂(97.9%)、血管紧张素Ⅱ受体阻滞剂(95.5%)、β受体阻滞剂(91.5%)、钙通道阻滞剂(87.8%)、血管紧张素转换酶抑制剂(78.4%)。[结论]影响依从性的主要因素为药物的不良反应。

[Objective] To study the compliance of patients with newly diagnosed hypertension on antihypertensive drugs and its influencing factors. [ Methods] 985 patients were newly diagnosed with mild or midrange hypertension. On the basis of 5 kinds of antihypertensive drugs, their prescriptions were optimizing according to the individual conditions of the patients The treatment lasted for 8 weeks. According to the controlling effects of blood pressure and adverse reactions of drug, antihypertensire drugs were adjusted, then the compliances of drug were compared. [Results] Sorted by intensity of compliance, the sequence of drug were diuretic （97.9%）, angiotensin Ⅱ receptor blocker （95.5%）, beta-blocker （91.5%）, calcium channel blocker （87.8%）, angiotensin converting enzyme inhibitor （78.4%）. [ Conclusion ] The influencing factors of patients＇ compliance may be adverse reactions of drugs.