摘要
[目的]通过测定急性脑梗死患者血液内IL-1、IL-6、TNF、TM水平,探讨细胞因子及TM在脑梗死发病机制中的作用及相互关系。[方法]用ELISA法测定68例急性脑梗死患者血液内IL-1、IL-6、TNF、TM的含量,并对IL-1、IL-6、TNF进行动态观察。[结果]急性脑梗死患者血液内IL-1、IL-6、TNF、TM含量明显升高(P<0.01),IL-1、TNF在发病d1即达高峰,随时间推移逐渐下降,而IL-6在较长时间内仍保持较高水平。[结论]多种细胞因子相互诱生、相互作用、形成动态的免疫调节网络,介导一系列连锁反应,在脑梗死的发病中起着重要作用。
[Objective] To detect the level of IL-1, IL-6, TNF and TM in acute cerebral infarction patients＇ blood and study the function and relationship of cytokines and TM on acute cerebral infarction pathogenesis. [Methods] We detected 68 cerebral infarction patients＇ IL-1, IL-6, TNF and TM level With ELISA, and continually observed their content. [Results] The content of IL-1, IL-6, TNF and TM in acute cerebral infarction patients＇ blood obviously increased （P 〈 0.01）, IL-1 and TNF reached a peak at the first day, then descended gradually, however, IL-6 had kept high level for long time. [Conclusions] Varieties of cytokines can reciprocally induce, interact and form dynamic immunity adjustment network, furthermore, give rise to many chain reactions, and have important inducing effect on cerebral infarction.
出处
《现代预防医学》
CAS
北大核心
2008年第5期974-975,共2页
Modern Preventive Medicine
基金
赤峰学院科研基金项目(ZRYB200612)
