EITOP方案治疗复发和难治性非霍奇金淋巴瘤疗效分析

Effect of EITOP Regimen on Recurrent and Refractory Non-Hodgkin's lymphoma

目的:探讨用足叶乙甙(VP-16,E)、异环磷酰胺(Ifosfamide,I)、吡柔比星(Pirarubicin,T)、长春新碱(VCR,O)、泼尼松(Prednisone,P)组成的EITOP方案治疗复发或难治非霍奇金淋巴瘤的疗效和毒性。方法:42例患者予EITOP方案治疗,异环磷酰胺1.2g.(m2)-1.d-1静脉滴注,d1～d5,吡柔比星30mg.(m2)-1.d-1静脉注射,d1～d3,长春新碱1.4mg.(m2)-1.d-1,静脉注射,d1,泼尼松40mg.(m2)-1.d-1口服,d1～d7,平均每3周为1周期,全组患者接受3个～8个周期治疗,平均4个周期。结果:42例患者接受EITOP方案化疗,完全缓解22例,部分缓解10例,总有效率76.19%,中位生存期为42个月,毒副作用主要为骨髓抑制。结论:EITOP方案是治疗复发或难治非霍奇金淋巴瘤的有效方案,毒性反应可耐受。

Objoctive To observe the effect and side effect s of EITOP regimen for patient s with recurrent and refractory Non-Hodgkin＇s lymphoma. Methods 60 mg.（m^2）^-1.d^-1 VP-16 （E） was administered iv by drop on dl,3,5; 1.2g.（m^2）^-1.d^-1Ifosfamide （IFO） iv by drop on dl-5 ; 30mg.（m^2）^-1.d^-1 Pirarubicin （THP）iv by drop on dl-3; 1.4 mg.（m^2）^-1.d^-1 VCR iv by drop on dl and 40mg.（m^2）^-1.d^-1 Prednisone was given on d1-7 .The mean of one chemotherapy period is 4 weeks,all the patients are obtained 3-10 periods＇treatment while Mean is 4 weeks. Results In all 42 patient s, 22 CR and 10PR, 76.19%ofrespense rate was achieved. Main toxicities were neutropenia and thrombocytopenia.Conclusion EITOP regimen can achieve a satisfied result s in the treatment of recurrent and refractory Non-Hodgkin＇s lymphoma with well tolerated toxicity.