2型糖尿病患者血清hs-CRP和TC/HDL-C联合检测的应用研究

Combined Detection of hs-CRP and TC/HDL-C in Type 2 Diabetes Mellitus

目的:探讨超敏C反应蛋白在2型糖尿病中的应用价值。方法:用OlympusAU2700全自动生化分析仪对72例2型糖尿病患者和65例正常对照组进行血清超敏C反应蛋白和各项血脂的含量的检测,并计算总胆固醇与高密度脂蛋白之比,后采用SAS统计软件进行统计学处理作对比分析。结果:2型糖尿病患者血清超敏C反应蛋白及总胆固醇与高密度脂蛋白之比明显升高,与健康对照组比较,差异有统计学意义(P<0.01和P<0.05)。结论:hs-CRP与血脂测定在预测2型糖尿病并发心血管疾病中具有重要的临床应用价值;2型糖尿病患者常伴有血脂紊乱,TC/HDL-C升高提示患动脉粥样硬化的危险性增大。

Objative To investigate the application of serum hs-CRP and the correlations between Them in type 2 diabetes. Methods The levels of serum hs-CRP and TC/HDL-C in 72 type 2 diabetis and 65 controls were detected by Olympus Au 2 700. Results The levels of serum hs-CRP and TC/HDL-C in type 2 diabetes group were much higher than those in control group （P〈0.01, P〈0.05）. Conclusion Serum hs-CRP level is associated with serum lipid level and inflammatory response might play an important role in the pathogenesis of type 2 diabetes. In type 2 diabetes there is an increased risk of development of cardiovascular diseases.