丽珠肠乐治疗溃疡性结肠炎的临床研究

CLINICAL STUDY OF BIFIDO BACTERIUM ON TREATMEAT OF ULCERATIVE COLITIS

目的:探讨溃疡性结肠炎的肠道菌群改变及双歧杆菌对溃疡性结肠炎的预防和治疗作用。方法:随机选取溃疡性结肠炎的患者78人,分成二组,治疗组:口服丽珠肠乐胶囊。对照组:口服氟哌酸胶囊,柳氮磺胺吡啶栓,直肠给药。疗程一个月。结果:溃疡性结肠炎的肠道内细菌数量双歧杆菌、乳杆菌显著下降(P<0.01),肠球菌显著增加(P<0.01)。结果:经丽珠肠乐治疗后,肠道内主要细菌的数量恢复正常,与对照组相比有显著差异(P<0.01);肠道粘膜病理及组织学改变基本恢复正常;临床症状改善上治疗组疗效高于对照组(P<0.01)。结论:微生态调节剂治疗溃疡性结肠炎效果显著,值得临床推广使用。

Objective：To study the microecological changes and the prevention and therapy by Bifido bacterium （ BF ） of Ulcerative colitis. Methods：78 cases were randomly divided two grous. Therapeutic group was given by oral BF. Control norfloxacin and suppository Sulfasalazine . Results：The results showed that the quantities of main bacteria in Ulcerative colitis such as Bifido bacterium and Lactobacillas decreased （p 〈0.01 ） ,while Enterococcus increased comparing with the control group （ p 〈 0.01 ）. In Bifido bacterium the quantities of the intestines main bacteria such as Bifido bacterium and Lactobaccillus increased （p 〈 0.01 ） while Enterococcus decreased with the control （p 〈0.01 ）. Pathologic and Uhrastructral observations showed the structure of intestines mucosa were restored to normal . Clinical symptom was significantly improved in therapeutic group compared with control group （p 〈 0.01 ）. Conclusion： It is very good that effect of therapy of Ulcerative colitis with Microecological modulator.