白血病患者血清VEGF、EGF联合检测的临床意义

THE EXPRESSIIONS OF SERUM VEGF AND EGF IN PATIENTS WITH LEUKENIA AND THE SIGNIFICANCE

目的:检测白血病患者血清中血管内皮生长因子(VEGF)与表皮生长因子(EGF)的浓度,探讨VEGF和EGF在白血病患者血液中的表达及二者之间的关系和意义。方法:应用酶联免疫技术(ELISA法)检测20例白血病患者及40名健康人血清中VEGF和EGF浓度。结果:40例白血病患者血清VEGF含量为398.6±114.8pg/ml,对照组血清VEGF的含量为108.5±50.6 pg/ml,两组比较具有显著的相关性(P<0.05);40例白血病患者血清EGF含量为1.80±0.52μg/L,40例正常对照组血清EGF含量为0.76±0.80μg/L,见表1。结论:白血病患者血清VEGF、EGF浓度显著高于健康对照组,且二者呈显著正相关。

Objective：To explore the levels of serum epidermal growth factor （EGF） and vascular endothelial growth factor （VEGF） in Patients With Leukemia and the relation of the two factors. Methods：The serum VEGF and EGF levels were measured by enzyme -linked immunosorbent assay （ELISA） in 40 patients with Leukemia and 40 healthy subjects respectively. Results：The serum VEGF level of Leukemia patients was 398.6 ± 114.8μg/ml and EGF level wasl. 80 ± 0.52μg/L; The serum VEGF level of healthy persons was 108.5 ± 50.6μg/ml/L and EGF level was 0.76 ± 0. 80μg/L （ P 〈 0. 05）. Conclusion：Serum levels of VEGF and EGF are significantly higher in patients with Leukemia than in healthy controls （ P 〈 0. 05）. There is obvious positive correlation between EGF and VEGF.