超声引导下肝穿刺活检在慢性乙型肝炎抗病毒治疗前后的应用研究

APPLIED STUDY ON HEPATIC PUNCTURE BIOPSY GUIDED BY UITRASOUND IN TREATMENT OF CHRONIC HEPATITIS B

目的:探讨超声引导下肝穿刺活检在慢性乙型肝炎抗病毒治疗前后的应用价值。方法:对36例临床拟行抗病毒治疗的肝炎患者进行了肝穿刺活检,有34例进行了抗病毒治疗,治疗后再次活检,对病理结果进行分析和对比研究。结果:治疗前后病理结果显示乙肝的炎症分级和纤维化分级均有不同程度的改善,前后对比有统计学意义,炎症分级改善更为明显。结论:超声引导下肝穿刺活检能提供客观的组织病理学依据,有利于临床作出准确的诊断、了解病变的活动性和发展阶段、选择合适的抗病毒治疗适应症、客观的评价疗效、指导用药。

Objective ：To explore the applied value of hepatic puncture biopsy （HPB） guided by ultrasound in antiviral therapy of patients with chronic hepatitis B （CHB）. Methods：Before antiviral therapy, 36 patients with CHB were performed HPB guided by ultrasound. After that,34 patients with CHB were given antiviral therapy and undergone HPB again. The results of pathological examinations were comparatively analysed and studied. Results： The results of pathological examinations before and after antiviral therapy showed that the Scales of the inflammation and liver fibrosis of patients with CHB were greatly improved, with statistical significance. Concluslon：Hepatic puncture biopsy guided by ultrasound can offer objective histopathology basis for clinical practice,which is favourahie to clinically accurate diagnosis, understanding of the activity and development stages of lesions, proper selection of clinical indication suitable for antiviral therapy , and objective evaluation of curative effects and instructions on medication.