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骨髓基质干细胞移植治疗脊髓损伤的研究进展 被引量：4

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摘要 脊髓损伤(spinal cord injury SCI)是一种致残率很高的疾病,且损伤后病理生理机制非常复杂因而脊髓损伤防治与再生修复是当今神经科学的重大难题。在临床上由于缺乏行之有效的治疗手段,长期以来人们对脊髓损伤的治疗态度是悲观的。近年来干细胞移植对损伤脊髓组织的修复倍受关注,尤其是骨髓基质干细胞移植治疗脊髓损伤成为近年研究热点。骨髓基质细胞是骨髓内造血干细胞以外的非造血干细胞,这类细胞具有高分化潜能,有向神经细胞分化的能力。
作者 代海平 徐波 潘秀丽
机构地区 牡丹江医学院附属红旗医院
出处 《牡丹江医学院学报》 2008年第1期82-85,共4页 Journal of Mudanjiang Medical University
关键词 脊髓损伤 骨髓基质干细胞 移植 治疗
分类号 R457.7 [医药卫生—治疗学] R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献15

  • 1Allen AR. Surgery of experimental lesion of spinal cord equivalent to crush injury of fractureed is location of spinal column. A prellmitaey report. JAMA1991 ;57:878 - 880.
  • 2VAQUERO J , ZUR ITA M, OYA S, et al. Early ad2ministration of methylp rednisolone decreases apop toticcell death after spinal cord injury [J]. Histol His2topathol, 2006, 21 (10) : 1091 - 1092.
  • 3HALL E D, SPR INGER J E. Neuro - protection andacute spinal cord injury: a reapp raisal[J]. Neuro - Rx, 2004, 1 ( 1 ) : 80 - 100.
  • 4Preckop DJ, Sekiya I, Colter DC, et al. Isolation and characterization of rapidly self - renewing stem cells from cultures ofhuman marrow stromal cells [J]. Cytotherapy, 2001,3 (5) : 393-396.
  • 5陈文芳,王连唐,石慧娟,廖月华,王浩.骨髓间充质干细胞定向分化为软骨细胞[J].中国病理生理杂志,2004,20(7):1195-1199. 被引量：13
  • 6Quirici N, Soligo D, Bossolasco P, et al. Isolation of bone marrow mesenehymal stem cells by anti - nerve growth factor receptorantibodies[J]. Exp Hematol, 2002, 30(7) : 783 -791.
  • 7Kopen GC , Preckop DJ . Marrow stromal cells migrate throughout forebrainand cerebellum, and they differentiate into astrocytes after injection intoneonatal mouse brains [ J ]. Proc Natl Acad Sci USA , 1999 ,96 (19) :10711 -10716.
  • 8Schwarz EJ, Alexander GM, Prockop DJ , et al . Multipotential marrow stromal cells transduced to L2DOPA :engraftment in a rat model of Parkinsondisease[J]. Hum Gene Ther , 1999 , 10 ( 15 ) : 2 539 - 2549.
  • 9Brazelton TR , Rossi FM, Keshet GI , et al . From marrow to brain : expressionof neuronal pherotypes in adult mice[ J]. Science ,2000 , 290 (5497) :1 775-1779.
  • 10Choop M,Zhang XH ,Li Y,et al ,Spinal cord injury in rat :treatment withbone marrow stromat cell transplantation [ J ]. Neuroreport ,2000 ,11 (13) :3001-3005.

二级参考文献13

  • 1[1]Owen M. Marrow stromal stem cells[J]. J Cell Sci, 1988,10 (Suppl): 63 - 76.
  • 2[2]Prockop. DJ Marrow stromal cells as stem cells for nonhematopoietic tissues[J]. Science, 1997, 276(5309): 71 - 74.
  • 3[3]Mackay AM, Beck SC, Murphy JM, et al. Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow[J]. Tissue Engineering, 1998, 4(4): 415-428.
  • 4[4]Frank Barry, Raymond E, Beisshan Liu, et al. Chondrogenic differentiation of mesenchymal stem cells from bone marrow:differentiation- dependent gene expression of matrix components[J]. Exp Cell Res, 2001,268(2): 189 - 200.
  • 5[5]Kulyk WM, Franklin JL, Hoffman LM. Sox9 expression during chondrogenesis in micromass cultures of embryonic limb mesenchyme[J]. Exp Cell Res, 2000, 255(2): 327- 332.
  • 6[6]De- Bari C, Dell'Accio F, Luyten FP. Human periosteumderived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age [ J ].Arthritis Rheum, 2001, 44(1): 85 - 95.
  • 7[8]Simmons DJ. Fracture healing perspective [J]. Clin Orthop,1985, 200(11):100- 113.
  • 8[10]Ballock RT, Heydemann A, Izumi T. Regulation of the expression of the type - Ⅱ collagen gene in periosteum - derived cells by three members of the transforming growth factor - beta superfamily[J]. J Orthop Res, 1997, 15(3): 463-467.
  • 9[11]Iwasaki M, Nakata K, Nakahara H, et al. Transforming growth factor - beta 1 stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum - derived cells[J]. Endocrinology, 1993, 132(4): 1603-1608.
  • 10[12]Tacchetti C, Tavella S, Dozin B, et al. Cell condensation in chondrogenic differentiation[J]. Exp Cell Res, 1992, 200 (1) :26 - 33.

共引文献12

同被引文献53

引证文献4

二级引证文献8

牡丹江医学院学报
2008年 第1期

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