摘要
建立一种反相高效液相色谱法测定利福昔明有关物质。以ODS-C8为固定相,乙腈-甲醇-缓冲溶液为流动相,检测波长为240nm,同时考察了方法的专属性。对有关物质的混合试样、降解试样和合格试样的测定结果表明,该方法专属性强,灵敏度高,简单准确,能有效检测利福昔明有关物质。
To establish a RP-HPLC method for determination related compounds of Rifaximin. In this study, ODS-Cs was adopted as stationary phase,solvent mixture composed of Acetonitrile：MeOH：buffer solution and the detection wavelength was 240 nm. The specificity of the method was also studied. The method is shown to be sensitive by method sample analysis. The RP-HPLC method is simple and sensitive,recommended in this paper is reliable for testing related compotmds in Rifaximin.
出处
《安徽化工》
CAS
2008年第1期68-70,共3页
Anhui Chemical Industry
