VEGF-C在非小细胞肺癌淋巴结转移中的意义

Significance of VEGF-C in non-small cell lung cancer with lymph node metastasis

目的探讨血管内皮生长因子-C(vascular endothelial growth factor-c,VEGF-C)在非小细胞肺癌(non-smallcell lung cancer,NSCLC)中的表达及其与临床病理特征之间的关系。方法采用免疫组化的方法检测80例NSCLC组织中VEGF-C及CD34的表达,分析VEGF-C和血管密度(microvessel density,MVD)、肿瘤组织类型、组织分化程度和淋巴结转移之间的关系。结果VEGF-C的表达与非小细胞肺癌的病理类型密切相关,其中在腺癌中表达率最高(P=0.030 8);在术中淋巴结检测为阳性的病例,VEGF-C的表达明显增强,有统计学意义(P=0.024 6)。VEGF-C的表达与肿瘤分化程度及肿瘤内新生血管密度无关。结论VEGF-C促使肺癌内淋巴管形成,促进肺癌淋巴结转移;是肺癌淋巴管转移的预测性指标。

Objective To study the relationship between VEGF-C expression and clinicopathologic characteristics of patients with non-small cell lung cancer （NSCLC）. Methods VEGF-C and CD34 expressions were detected in 80 patients with NSCLC by immunohistochemical staining. The correlation of VEGF-C to microvessel density （MVD）, histological type, differentiation and lymphatic metastasis were analyzed. Results The expression of VEGF-C correlated highly with histology, especially in adenocarcinoma （ P = 0. 030 8） and lymphatic metastasis （P = 0. 024 6）. The expression of VEGF-C protein was negatively related with the differentiation of NSCLC and MVD. Conclusion VEGF-C promotes intratumoral lymph angiogenesis and lymph node metastasis, The high expression of VEGF-C indicates high risk of lymphatic metastasis.