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Wnt信号通路与干细胞定向分化

WNT SIGNALING PATHWAY AND STEM CELL DIFFERENTIATION
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摘要 Wnt信号通路在胚胎发育过程中参与背腹轴的形成、细胞极性的建立以及决定细胞命运.利用干细胞定向分化模型可在体外培养条件下探索Wnt信号通路在哺乳动物早期胚胎发育过程中的分子机理,了解其信号网络对干细胞定向分化中各个事件的调控机制.本文通过综合近期Wnt信号通路的研究,阐述经典Wnt信号通路(Canonical Wnt signaling pathway)在干细胞定向分化中的作用. Wnt signaling pathway has been indicated to play key roles in the formation of dorsal and ventral axis,the generation of cell polarity and the specification of cell fate in embryonic development.With the establishment of stem cell in vitro model of early mammalian development,we are able to figure out the specific molecular mechanism of Wnt signaling pathway in the regulation of stem cell differentiation.Recent advances in our understanding of Canonical Wnt signaling pathway,detailed in this review,have provided new insights essential for manipulating stem cell differentiation.
作者 谭效忠 黄舒扬 杜德强 孟小倩
机构地区 山东师范大学生命科学学院
出处 《山东师范大学学报（自然科学版）》 CAS 2008年第1期137-139,共3页 Journal of Shandong Normal University(Natural Science)
关键词 WNT信号通路 干细胞 分化 Wnt signaling stem cell differentiation
分类号 Q132.3 [生物学—普通生物学]
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参考文献20

  • 1Huwelsken J, Behrens J.The Wnt signaling pathway[J]. J Cell Scien, 2002, (155): 3 977- 3 978.
  • 2C Liu, Y Li, M Semenov, et al. Control of β - Catenin Phosphorylation/Degradation by a Dual - Kinase Mechanism, Cell, Volume 108, (Issue 6) : 837 - 847.
  • 3David J Mulholland, Shoukat Dedhar, Gerhard A Coetzee, et al. Interaction of Nuclear Receptors with the Wnt/β - Catenin/Tcf Signaling Axis: Wnt You Like to Know? Endocr Rev, 2005, (26): 898-915.
  • 4Eek-hoon Jho, Tong Zhang, Claire Domon, et al. Wnt/β- Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway[J]. Mol. Cell. Biol., 2002, (22): 1 172- 1 183.
  • 5Jose M Gonzalez- Sancho, Keith R Brennan, Leslie A. Castelo-Soccio, et al. Wnt Proteins Induce Dishevelled Phosphorylation via an LRPS/6 - Independent Mechanism, Irrespective of Their Ability To Stabilize β- catenin[ J ]. Mol Cell Biol,2004, (24): 4 757- 4 768.
  • 6Janet Y Leung, Frank T Kolligs, et al. Activation of Axin2 Expression by β- Catenin - T Cell Factor. A feedback repressor pathway regulating Wnt signaling[J]. J Biol Chem, 2002, (277) : 21 657 - 21 665.
  • 7Coleman Lindsley R, Jennifer G Gill, Michael Kyba et al. Canonical Wnt signaling is required for development of embryonic stem cell - derived mesoderm Development[J]. 2006, (133): 3 787- 3 796.
  • 8Zhongling Feng, Ewa Carrier. A role of Wnt signalling pathway in the hematopoietic differentiation of murine embryonic stem cells[J]. Nature, 2003, (423) :409 - 414.
  • 9Reya T, Duncan A W, AiUes Letal, et al. A role for Wnt signaling in Self - renewal Of haematopoietic stem cells[ J ]. Nature, 2003, (423) : 409 - 414.
  • 10Peggy Kirstetter, Kristina Anderson, Bo T Porse, et al. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block[J]. Nat Immunol, 2006, (7) : 1 048 - 1 056.

二级参考文献43

  • 1Oda E, Ohki R, Murasawa H, et al. Noxa, a BH3 - only member of the Bcl - 2 family and candidate mediator of p53 - induced apoptosis[ J ]. Science,2000, (288): 1 053 ～ 1 058.
  • 2Nakano K, Vousden K H. PUMA, a novel proapoptotic gene, is induced by p53[ J ]. Mol Cell ,2001, (7): 683 ～ 694.
  • 3Yu J,Zhang L, Hwang P M,et al. PUMA induces the rapid apoptosis of colorectal cancer Cells[J] .Mol Cell,2001,(7):673～ 682.
  • 4Lin M T, Chang C C, Chen S T, et al. Cyr61 Rxpression Confers Resistance to Apoptosis in Breast Cancer MCF - 7 Cells by a Mechanism of NF - { kappa}B - dependent XIAP Up - Regulation[J] .J Biol Chem,2004, (279) :24 015 ～ 24 023.
  • 5Hishikawa K,Oemar B S,Tanner F C,et al.Connective Tissue Growth Factor Induces Apoptosis in Human Breast Cancer Cell Line MCF- 7[ J ].J Biol Chem, 1999, (274) :37 461 ～ 37 466.
  • 6Hu S, Snipas S J, Vincenz C, et al. Caspase - 14 is a novel developmentally regulated protease[ J]. J Biol Chem, 1998, (273) :29 648 ～ 29 653.
  • 7Soon L L, Yie T A, Shvarts A, et al. Overexpression of WISP - 1 downregulated motility and invasion of lung cancer cells through inhibition of Rac activation[J].J Biol Chem,2003, (278): 11 465～ 11 470.
  • 8Shimo T,Kubota S,Kondo S,et al.Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line [J]. Cancer Lett, 2001, (174) :57 ～ 64.
  • 9Babic A M, Kireeva M L, Kolesnikova T V, et al. CYR61, a product of a growth factor- inducible immediate early gene, promotes angiogenesis and tumor growth[ J] .Proc Natl Acad Sci, 1998, (95):6 355 ～ 6 360.
  • 10Xie D, Miller C W, O' Kelly J, et al. Breast cancer. Cyr61 is overepressed, estrogen- inducible, and associated with more advanced disease [J]. J Biol Chem,2001, (276): 14 187 ～ 14 194.

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山东师范大学学报（自然科学版）
2008年 第1期

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