艾司西酞普兰与帕罗西汀治疗惊恐障碍的比较

Comparison of escitalopram and paroxetine in treatment of panic disorder

目的探讨艾司西酞普兰对惊恐障碍患者的疗效及不良反应。方法将66例惊恐障碍患者随机分为艾司西酞普兰组和帕罗西汀组,疗程8周,并用汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)、抗抑郁药不良反应评定量表(SERS)对患者治疗前后进行评估。结果在治疗的第1周、第2周末艾司西酞普兰组的HAMA分值均低于对照组,而在4、6、8周末,两组患者的HAMA分值差异无统计学意义。在治疗8周末时,艾司西酞普兰组治愈率为64.5%,有效率为90.3%,帕罗西汀组分别为63.3%、90.0%。两组差异无统计学意义。在不良反应方面,两组差异无统计学意义。结论艾司西酞普兰治疗惊恐障碍疗效与帕罗西汀相当,不良反应无明显差异。

Objective： To investigate the chnical efficacy and side effects of escitalopram in treating patients with panic disorder. Methods： Sixty-six patients with panic disorder were randomized divided into two groups. Patients in study group were treated with escitalopram and the control group were treated with paroxetine. All the subjects were rated by Hamilton Rating Scale for Anxiety （HAMA）, Hamiton Rating Scale for Depression and Rating Scale for Side Effects （SERS） at the baseline and the end of week one , two, four, six, eight, respectively. Rzesults：Score of HAMA in the study group was significantly lower than that in the control group at the end of the first two weeks, but there were no significant differences between the two groups in both clinical effect and side effects at the end of week 4, 6, 8. The remission and response rates were 64. 5% and 90.3% respectively in the study group at the end of week 8 according to the HAMA score of change. The remission and response rates were 63.3% and 90.0% respectively in paroxetine group, with no statistical difference between the two groups. Conclusion：There is no significant difference betwe escitalopram and paroxetine in treating patients with panic disorder in terms of clinical efficacy and and adverse effects.