自体瘤苗免疫治疗的临床观察及意义

Clinical Observation and Significance of Auto-tumor Vaccine Immunotherapy

目的对自体瘤苗免疫治疗的患者进行临床观察与护理及生存率分析，探讨自体瘤苗免疫治疗的疗效及预后。方法回顾性分析自体瘤苗免疫治疗组95例患者及对照组76例患者治疗前及治疗后1个月临床免疫指标变化及进行生存情况逐年随访。结果瘤苗组的患者外周血中除了NK活性无明显变化外，CD3，CD4，CD8的百分含量，CD4／CD8都较治疗前有明显改变，且差异有统计学意义（P〈0.05）；对照组的患者外周血CD3，CD4，CD8的百分含量，CD4／CD8和NK活性差异与治疗前比较都无统计学意义。瘤苗组除IgG值升高，其他与对照组体液免疫均无明显差异；与肿瘤疫苗治疗有关的不良反应最常见的是疫苗注射部位的局部反应。即局部的自限性红斑、硬结或搔痒，少数出现低热、头疼、疲乏无力等；瘤苗组患者与对照组患者生存率比较，差异有统计学意义，瘤苗组生存率截至随访日期为62.46％，对照组为43.39％。结论肿瘤疫苗治疗肿瘤可作为安全、副反应小的肿瘤生物治疗方法之一，对延长患者生存时间、改善生活质量等具有重要意义。

Objective To investigate the curative effect and prognosis of auto-tumor vaccine immunotherapy by using clinical observation, nursing and survival rate on patients who underwent the auto-tumor vaccine immunotherapy. Methods The changes of clinic immunity target of 95 patients who underwent auto-tumor vaccine immunotherapy were compared with 76 patients in the control group during the pretherapy and post-treatment, as well as analyzing survival rate on patients of both two groups year by year. Results Content of CD3, CD4, CD8 and the specific value of CD4/CD8 changed obviously except for cell natural killer cell in peripheral blood of tumor vaccine group, yet it was not statistically significant about the disparity of control group. There was no obviously difference on humoral immunity between tumor vaccine group and control group besides the increasing of IgG. And the main adverse effect about the healing of auto-tumor vaccine was local response, such as erythema, induration or itching, low-grade fever, headache and fatigue appeared on a few patient. The disparity on survival rate between two groups was statistical significance. Survival rate of patient of auto-tumor vaccine was 62.46%, and 43.39% was control group. Conclusion Auto-tumor vaccine therapy is one of biotherapy on tumor, which is safe, minor side reaction ; And it is significance on prolonging patient＇s live time, improving quality of life.