摘要
目的合成并表征塞克硝唑苯甲酸酯。方法以吡啶为缚酸剂，塞克硝唑与苯甲酰氯反应制备目标产物。红外和氢核磁进行结构确证。结果产物为类白色片状结晶，mp.137-138.5℃，收率71.5％。结论合成了产物并确证了结构；采用油水两相混合液结晶，可提高收率。
Aim To synthesize and characterilize secnidazole benzoate. Method Pyridine being used as acid absorbent,secnidazole reacts with benzoyl chloride to afford the product,the structure of which was identificated with FT-IR and ^1H NMR. Results The product as off-white crystal was obtained, mp. at 137-138.5℃, yield being 71.5%. Conclusion The product was prepared and characterilized; yield of the product was improved, which was crystallized in oil/water mixture.
出处
《安徽医药》
CAS
2008年第2期112-113,共2页
Anhui Medical and Pharmaceutical Journal
关键词
塞克硝唑苯甲酸酯
合成
表征
secnidazole benzoate
synthesis
characterilization
