357株大肠埃希菌耐药性监测

Surveillance on drug resistance of 357 strains escherichia coli in recent three years

目的对本院近3年大肠埃希菌进行常用抗生素的耐药监测及产ESBLs检出率进行比较分析。方法药敏实验和双纸片协同试验对我院2004年-2006年临床分离的357株大肠埃希菌进行监测分析。结果大肠埃希菌对氨苄西林、环丙沙星、左氧氟沙星的耐药率都在50％以上，对头孢呋辛、头孢噻肟、头孢曲松、头孢他啶、氨曲南、庆大霉素、阿米卡星的耐药率都在40％左右，对哌拉西林／他唑巴坦、头孢西丁、头孢吡肟耐药率为20％左右，对碳青霉烯类抗菌药物亚胺培南／西司他丁、美罗培南全部敏感。大肠埃希菌ESBLs检出率2004-2006年分别为36.5％、38.7％、41.6％。结论大肠埃希菌对绝大部分抗菌药物的耐药率均逐年增加，大肠埃希菌产ESBLs率呈逐年上升的趋势，积极加强耐药监测，合理、规范选用抗菌药物，才能控制耐药菌株的出现和传播。

Aim To study the resistance and its tendency of E. coli to antibiotics and ESBLs-producing analysis in recent three years. Methods Drug susceptibility test and double disc synergy test were employed to analyze the drug sensitivities of 357 strains clinical isolated E.coli from 2004 to 2006 in Susong People＇s Hospital. Results The resistance rates of E.coli to ampicillin, ciprofloxacin levofloxacin exceeded 50% , and they were about 40% to cefuroxime, cefotaxime, ceftriaxone, ceftazidime, aztreonam, gentamicin, amikacin. In addition,the resistant rates were about 20% to piperacillin/tazobactam, cefoxitin, cefepime, there was no resistance to imipenem and meropenem. The detection rates of ESBLs to E.coli was 36.5%, 38.7% ,and 41.6% in 2004,2005,2006 respectively. Conclusions The resistance rates of E. coli to antibiotics and the rates of ESBLs-producing ascended year by year. More attention should be paid to the detection of drug resistance strains and antibiotics should be used rationally and regularly.