小剂量尿激酶溶栓联合氯吡格雷治疗不稳定型心绞痛的临床研究

Clinical Outcomes of Low-dose Urokinase Combined with Clopidogrel in Long-term Treatment of Unstable Angina Pectoris

【目的】探讨小剂量长疗程尿激酶溶栓联合氯吡格雷治疗不稳定型心绞痛(UAP)的疗效.【方法】将86例UAP患者非选择性地分为联合治疗组及常规治疗组,联合治疗组(43例)应用小剂量长疗程尿激酶联合氯吡格雷治疗,观察心绞痛缓解率及心电图改善率并与常规治疗组(43例)进行比较。【结果】联合治疗组心绞痛缓解总有效率90.7%,心电图改善总有效率86.05%;均明显高于常规治疗组(69.77%、65.12%,P均<0.05)。【结论】小剂量长疗程尿激酶溶栓联合氯吡格雷治疗不稳定型心绞痛有较好的疗效。

[Objective]To explore the effect of low dose urokinase （uk） combined with clopidogrel in longterm treatment of unstable angina pectoris. [Methods]Eighty six patients with unstable angina pectoris were randomly divided into two groups：treatment group in which 43 cases were additionally treated by low-dose urokinase combined with clopidogrel, and control group in which 43 cases were treated by routine treatment. The remission rate of angina pectoris and the improvement rate of electrocardiogram （ECG） in both groups were observed and compared. [Results] The total remission rate in treatment group was 90.7% and the total improvement rate of ECG was 86.05 %, which were significantly higher than those in control group（69.77 % and 65.12%, P〈0.05 ）. [Conclusion] Low-dose urokinase combined with clopidogrel in the treatment of unstable angina pectoris is effective for unstable angina pectoris patients.