以酮症起病的青少年糖尿病患者的临床特征

Clinical Characteristics of Juvenile Diabetic Patients with Ketosis-onset

【目的】探讨以酮症起病的青少年糖尿病患者的临床特征。【方法】将94例新发青少年糖尿病患者,分为酮症起病组和非酮症起病组,比较两组患者的年龄、性别、家族史和胰岛功能等方面的差异,并比较两组患者在随访6个月时的代谢控制和治疗方式的差异。【结果】酮症起病组的起病年龄、BMI、FCP、2hPCP、TG要显著低于非酮症组,FPG、体重下降的比例和自身抗体阳性率要显著高于非酮症组。随访6个月时,酮症起病组的HbA1c高于非酮症组,FCP、2hPCP和体重上升的比例低于非酮症组。酮症起病组单独使用胰岛素的比例高于非酮症组,单独使用药物和饮食运动治疗的比例,酮症起病组显著低于非酮症组。【结论】以酮症起病的青少年糖尿病患者与非酮症起病者临床特征明显不同,而且二者在随访6个月时的胰岛功能、治疗方式存在明显差异。

[Objective] To investigate the clinical characteristics of juvenile diabetic patients with ketosisonset. [Methods] Ninety four new-onset juvenile diabetic patients were divided into ketosis and non-ketosis group. Age, gender, family history and beta-cell function were compared in the two groups. The differences in metabolic control and mode of treatment during the six-month follow-up were compared as well. [Results] There were significant differences in some characteristics between two groups, including onset age, BMI, FCP, 2hPCP, TG, FPG, incidence of weigh loss and autoantibodies. In 6-month follow-up, there were significant differences in HbAlc, FCP, 2hPCP and weigh gain between two groups. About the mode of treatment, more patients in ketosis group accepted insulin therapy alone and the patients without ketosis would like to use oral drugs or dietary and exercise therapy. [Conclusion] The clinical characteristics of juvenile diabetic patients with ketosis-onset are quite different with those of patients without ketosis, and there are some differences in the β-cell function and the mode of treatment.