微波辐射致家兔小脑运动性学习记忆功能障碍及屏蔽材料的防护作用

Dysfunction of Cerebellar Motor Learning in Rabbits by Microwave Irradiation and Protection of Shielding Material

目的]探讨微波辐射对家兔小脑运动性学习记忆功能的损伤效应,评价铝箔对微波辐射的防护效果。方法][[选择已经建立牢固瞬膜条件反射的家兔18只(雌雄各半),随机均分为对照组、无屏蔽组和铝箔屏蔽组,以平均功率密度为90mW/cm2的微波持续辐射30min,检测各组家兔在微波辐射结束后瞬膜条件反射的变化(辐射结束后0、3、24和72h共4个观察时相点)。[结果]无屏蔽组瞬膜条件反射在微波辐射后0h完全丧失(阳性率为0),3h后明显恢复[阳性率为(65.00±8.91)%],但仍低于对照组[阳性率为(94.17±3.35)%],P<0.01;24h基本恢复至正常水平[阳性率为(82.50±8.49)%],P>0.05;屏蔽组瞬膜条件反射在微波辐射前后没有显著变化(均P>0.05)。[结论]90mW/cm2的微波辐射可导致无屏蔽组家兔小脑运动性学习记忆功能障碍,而铝箔屏蔽组家兔小脑运动性学习记忆功能没有受到明显损害。

[ Objective ] To study the injury of cerebellar motor learning in rabbits by microwave irradiation, and to evaluate the protection effect of aluminium foil. [ Methods ] Eighteen rabbits were trained for 7 days to form eye blink conditional reflex, and then divided randomly into control, non shielded and aluminium foil shielded groups, to detect the change of eye blink conditional reflex in rabbits after 90 mW/cm^2 （ average power density ） microwave irradiation for 30 min in every groups. [ Results ] Rabbits of non shielded group had no eye blink conditional reflex at 0 h of the end of irradiation, but 3 h later the conditional reflex recovered partly, and 24 h later the reflex recovered completely. The eye blink conditional reflex of rabbits did not change significantly after microwave irradiation in aluminium foil shielded group. [ Conclusion] 90 mW/cm^2 microwave irradiation induced dysfunction of rabbits cerebellar motor learning in non shielded group, but could be protected by aluminium foil shield.