琥珀酸美托洛尔缓释片治疗慢性充血性心功能不全的疗效观察

Observation of curative effect of metoprolol succinate sustdined-release table in the treatment of chronic congestive heart failure

目的:观察琥珀酸美托洛尔缓释片治疗慢性充血性心力衰竭的疗效。方法:慢性充血性心力衰竭患者89例,随机分为对照组44例与治疗组45例。对照组给予常规抗心力衰竭治疗;治疗组在对照组治疗基础上加用琥珀酸美托洛尔缓释片47.5 mg,1次/d,逐渐增加至97 mg,1次/d。结果:治疗组临床症状改善总有效率为88.9%,明显高于对照组72.7%(P<0.05);两组治疗后心脏射血分数、B型钠尿肽较治疗前明显改善(P<0.01),且治疗组优于对照组(P<0.05);患者再发心力衰竭及心血管原因的死亡均减少。结论:琥珀酸美托洛尔缓释片在常规治疗心力衰竭基础上能显著改善患者临床症状及心功能,并有利于心力衰竭患者的二级预防。

Objective To investigate the curative effect of metoprolol succinate sustdined-release tablet in treating chronic congestive heart failure. Methods A total of 89 patients with chronic congestive heart failure were randomly divided into treatment group and control group. Control group was treated with conventional therapy for heart failure, while the treatment group was treated with metoprolol succinate sustdined-release tablet at an initial dose of 11.88 mg once a day but gradually increased to 97 mg once a day,in addition to the conventional therapy. Results The total responsive rate in the treatment group（88.9%） was significantly higher than in control group（72.3%） （P〈0.05）. The ejection fraction in both groups had significant improvement as compared with before treatment（P 〈0.01）, with the treatment group showing a better improvement than in control group（P〈0.05）. Conclusion Administration of metoprolol succinate sustdined-release tablet plus the conventional therapy can significantly improve the clinical symptoms and cardiac function in patients with chronic congestive heart failure.