应用ROC曲线评价白介素-6在肿瘤肝转移中的诊断价值

Diagnostic value of interleukin-6 in liver metastasis using receiver operating characteristic curve

目的:研究白介素-6水平对肿瘤肝转移的诊断价值。方法:测定42例肿瘤无转移患者、48例肿瘤肝转移患者和50名健康体检者血清白介素-6水平,应用受试者工作特征曲线进行评价。结果:肿瘤肝转移组白介素-6水平高于对照组和肿瘤无转移组,差异有统计学意义(P<0.05);肿瘤无转移组白介素-6水平高于对照组,差异有统计学意义(P<0.05)。血清白介素-6的受试者工作特征曲线下面积为0.846,白介素-6的最优截断点约为12 pg/mL,灵敏度和特异度分别为66.7%和80.6%。结论:通过受试者工作特征曲线评价,白介素-6可作为肿瘤肝转移诊断的临床指标。

Objective To evaluate the diagnostic value of interleukin-6 in liver metastasis. Methods Serum interleukin-6 was determined in 42 patients with solid tumor without metastasis, 48 patients with liver metastasis, and 50 healthy controls. The receiver operating characteristic curve was used to evaluate diagnostic value of interleukin-6. Results Serum interleukin-6 in liver metastasis was higher than solid tumor without metastasis and healthy controls （P〈0. 05）. Serum interleukin-6 in solid tumor without metastasis was higher than healthy controls （P 〈 0. 05）. The area under receiver operating characteristic curve of interleukin-6 was 0. 846. The optimum cut-off value of interleukin-6 was 12 pg/mL. The sensitivity and specificity were 66.7 % and 80.6 %. Conclusion Serum interleukin-6 level is a potent clinical marker in solid tumor with liver metastasis through receiver operating characteristic curve evaluation.