记忆B细胞与血清记忆

Memory B cells and serological memory

记忆B细胞被认为是记忆干细胞，通过抗原依赖和非抗原依赖的方式，能转化为浆细胞而产生抗体。B细胞的记忆形成涉及静止记忆B细胞和长寿命浆细胞。尽管已知这些细胞来源于生发中心，但刺激生发中心B细胞进入并维持记忆池所需的信号和环境尚不清楚。且它们是怎样从生发中心迁出，哪些因素决定其长期存活，记忆B细胞池与浆细胞池的组成和容量是多少等都还不十分清楚。这些问题的解决对免疫调控，防治自身免疫性疾病有重要的价值。

Memory B cells behave as ＇ memory stem cells＇ capable of generating plasma cells and antibodies in an antigen-dependent as well as in an antigen-independent fashion. Memory B-cells involves in two populations of quiescent memory B cells and long-lived plasma cells. Although it is clear that both of them generate from germinal centers, the signal and circumstances that trigger germinal-centre B cells to enter and then persist in memory compartment are poorly defined. Also, how they migrate from germinal centers, how they survive for a long time and what determines the overall size and composition of the memory B-cell and plasma-cell compartments are still unknown. The problems remain resolved, which will play an important role in immune regulation and prevention of self-immune diseases.