霉酚酸酯治疗紫癜性肾炎的临床观察

Efficacy and Safety of Mycophemolate Mofeil in Nephritis of Schonlein-Henoch Purpura

目的:研究霉酚酸酯对过敏性紫癜性肾炎的疗效。方法:28例过敏性紫癜性肾炎病人,给予足量强的松+霉酚酸酯治疗,治疗3个月后比较治疗前后的24h尿蛋白定量、血白蛋白、肝功、血脂、肾功、凝血酶原时间、活化部分凝血活酶时间、1h尿红细胞排泄率。结果:霉酚酸酯能降低尿蛋白,减轻血尿,改善肾功。结论:霉酚酸酯治疗过敏性紫癜性肾炎安全有效,副作用小。

Objective ： To study efficacy and safety of Mycophemolate Mofeil （ MMF ） in nephritis of Schonlein-Henoch purpura.Methods：The 28 patients of nephritis of Schonlein-Henoch purpura, were applied Prednisone Acetate and MMF （ 1.5-2.0g/d ）, then compared 24 hours urinary protein quantitation, blood albumin, cholesterin （ CH ）, triglyceride （ TG ）, blood urea nitrogen （ Bun ）, creatinine （ Cr ）, fibrinogen （ Fib ）, prothrombin time （ PT ） and activated partial thromboplastin time （ APTT ） after three- monthtreatment.Results ： MMF could decrease urinary proteln, improve renal function and hematuria, therapeutic efficacy were significantly （ P 〈 0.05 ） .Conclusion ： MMF is an effective and safety drug in nephritis of Schonlein-Henoch purpura.