摘要
蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)是脑动脉瘤患者死亡和残疾的主要原因之一。内皮素(ET)在SAH后CVS的发生中起着重要作用。文章从基础和临床两个方面阐述了ET在CVS中的作用,并就针对ET治疗CVS的前景做了展望。
Cerebral vasospasm (CVS) following subarachnoid hemorrhage (SAH) is one of the leading causes of death and disability in patients with intracranial aneurysms. Endothelin (ET) plays important a role in the occurrence of CVS following SAH. This article expounds the effect of ET on CVS both from clinical and basic aspects, and it also prospects the treatment of CVS targeted ET.
出处
《国际脑血管病杂志》
2008年第1期63-67,共5页
International Journal of Cerebrovascular Diseases
关键词
内皮素
脑血管痉挛
蛛网膜下腔出血
内皮素受体
信号转导
内皮素受体拮抗剂
内皮素转换酶抑制剂
endothelin
cerebral vasospasm
subarachnoid hemorrhage
endothelin receptor
signal transduction
endothelin receptor antagonist
endothelin converting enzyme inhibitor