黄芪对老年肺心病者电镜下血小板形态变化的影响

Influence of Huang Qi on the morphologyical changes of platelet under electron microscop in elderly pulmonary heart Disease patients

目的肺心病患者血小板聚集和释放功能增加，肺小动脉血栓形成；黄芪则有改善血液流变学异常，抑制亢进的血小板功能。本文观测黄芪对肺心病血小板形态的影响。方法选择老年肺心病４０例，随机分成２组，各２０例。对照组：采用常规治疗，实验组则在此基础上加黄芪静滴。在治疗前、后分别于对照组和实验组抽血，观测电镜下血小板分类计数，用ｔ检验和相关分析行统计学处理。结果肺心病患者聚集型血小板明显增多（３８．５±９．８％，２５．９±１０．４９％），聚集型血小板与氧分压呈负相关（ｒ＝０．５５，Ｐ＜０．０５）。黄芪治疗后，聚集型血小板减少（３８±２％，２２±１．４％）病程亦短于对照组（２８±１１天，２１±９天，Ｐ＜０．０５）。结论提示黄芪可抑制亢进的血小板功能，可促进肺心病患者康复，缩短病程。

Objective In cor pulmonale patients,there are increased platelet aggregation and releasing function and formation of thrombosis in small pulmonary artery.Huang Qi could alter abnormal coagulation and inhibit hyperfunction of platelet.The aim of this article was to observe the Huang Qi effect on morpholgical change of platelet in these patients.Methods 40 cases of elderly cor pulmonale patients were divided into two groups of 20 cases each.The control group was treated routinely,and in the study group Huang Qi was added.cases In all the classfied counting of platelet was performed under electron microscope t test was used for statistical analysis.Results It was found that the aggregated type of platelet was remarably increased(38 5±9 8%,25 9±10 4%, P <0 05) and there was a negative correlation between aggregated type of platelet and PaO 2( r =0 55 P <0 05) .After treated with Huang Qi ,aggregated type of platelet was markably decreased comparing with the control group(38±2 1% 22±1 9% P <0 05).The course of the disease was shortened as well(28±11 to 21±9d, P <0 05). Conclusions It was shown that Huang Qi could inhibit the hyperfunction of platelet promote the recovery and shorten the course in cor pulmonale patients