洛伐他汀及阿司匹林对冠心病患者载脂蛋白B的影响

The effects of lovastatin and aspirin on Apolipoprotein B in patients with coronary artery disease

目的:探讨洛伐他汀及阿司匹林对冠心病患者载脂蛋白B(Apo B)的影响。方法:观察218例冠心病患者的载脂蛋白B(Apo B)在用药前后的变化。其中洛伐他汀组74例,阿司匹林组58例,洛伐他汀和阿司匹林联用组86例。结果:3组患者用药前后载脂蛋白B(Apo B)的改变差异均有统计学意义(P<0.05),而洛伐他汀及阿司匹林联用组用药后载脂蛋白B(Apo B)的浓度与另两组用药后载脂蛋白B(Apo B)的浓度比较差异亦有统计学意义(P<0.01)。结论:洛伐他汀和阿司匹林联用对载脂蛋白B(Apo B)优于单一使用洛伐他汀或阿司匹林。

Objective To study the effects of lovastatin and aspirin on Apolipsprotein B （Apo B） in patients with coronary artery disease. Method The changes of apoB concentration before and after treatment in 218 patients with coronary artery disease were investigated. Among these patients, 74 were in lovastatin group, 58 in aspirin group and 86 in lovastatin plus aspirin group. Results The Apo B concentrations in the three groups after the treatment were significantly lower than those before the treatment （ P 〈 0.05）. In addition, the Apo B concentration in lovastatin plus aspirin group was significantly lower than those in the other two groups after thetreatment （P 〈 0.01 ）. Condusion The reduction effects of lovastatin plus aspirin on Apo B concentration is superior to those of single lovastatin or aspirin.