韭子对小鼠T细胞亚群的影响

Effects of Semen Allii Tuberosi on T cells subsets of mice

目的:研究中药韭子对小鼠的免疫调节作用。方法:环磷酰胺腹腔注射建立小鼠免疫功能低下模型,应用流式细胞仪对小鼠T细胞亚群进行检测。结果:韭子可改善环磷酰胺引起的CD4+亚群比例的降低、CD4+/CD8+比值的降低,说明它对模型小鼠T细胞功能有增强作用,并通过增强CD4+细胞调整CD4+/CD8+的比例失调。结论:韭子不仅对细胞免疫功能低下具有免疫增强作用,还具有较好的免疫调节作用。

Objective - To study the immunomodulation effects of Semen Allii Tuberosi （SAT）. Methods - An immunosuppressive animal model was established by cyciophosphamide （CY）. The T lymphocyte subsets were determined by flow cytometry （FCAS methods）. Results-SAT could efficiently improved the reduction in the proportion of CD4^＋ subsets and in the ratio of CD4＋/CD8^＋. SAT could enhance the function of T-cells in mice and redress the maladjustment in the ratio of CD4^＋/CD8^＋ by enhancing CD4^＋ cells. Conclusion： SAT can enhance the immunological function in the immunosuppressive mice, and therefore,is a valuable immune-enhancer.