非小细胞肺癌脑膜转移12例临床分析

Clinical analysis of 12 non-small cell lung cancer cases with meningeal metastases

目的通过对12例非小细胞肺癌脑膜转移病例的分析,探讨该病的诊断及治疗。方法12例经临床、影像学或脑脊液(CSF)细胞学检查证实的非小细胞肺癌脑膜转移患者,3例全脑放疗,8例全脑放疗加全身化疗,1例放弃治疗。结果3例单纯放疗者中1例PR,2例SD,中位生存4.2个月;8例全脑放疗加全身化疗者中4例PR,3例SD,1例PD,中位生存6.1个月;1例放弃治疗者存活1个月。结论MRI结合CSF细胞学检查有助于该病诊断,放疗加化疗疗效优于单纯放疗。

Objective To discuss the diagnosis and treatment of this disease through the analysis of 12 non-small cell lung cancer cases with meningeal metastases. Methods All 12 cases were confirmed with non-small cell lung cancer and meningeal metastases through clinical presentations, imageology or cerebrospinal fluid （CSF） cytology. 3 cases received whole brain radiation therapy. 8 cases received whole brain radiation therapy and chemotherapy. 1 case refused treatment. Results Among 3 cases receiving single radiation therapy, PR case was 1, SD cases were 2, median survival time was 4.2 months. Among 8 cases receiving whole brain radiation therapy and chemotherapy, PR cases were 4, SD cases were 3, PD case was 1, median survival time was 6. 1 months. 1 case refusing treatment survived 1 month. Conclusion MRI combined with CSF cytology was helpful to the diagnosis of this disease. The efficacy on the radiotherapy plus chemotherapy was better than single radiotherapy.