磺酸水杨酸催化一锅合成3,4-二氢嘧啶-2(1H)-酮

Synthesis of 3,4-dihydropyrimidin-2(1H)-one Derivatives Using Sulfonic Salicylic Acid as Catalyst

介绍了用磺酸水杨酸作催化剂，在无溶剂条件下，利用Biginelli反应，一锅合成3，4-二氢嘧啶-2（1H）-酮的方法。这种方法和传统的Biginelli反应条件比较，有反应时间短（4～7h）和收率高（71％～96％）的特点。

A simple and effective synthesis of 3,4 - dihydropyrimidin - 2（1H） - one derivatives from aldehydes, 1,3 - diearbonyl compounds and urea using Sulfonic salicylic acid as catalyst under solvent- free conditions is described. Compared with the classical BigineUi reaction conditions, this new method has the advantage of excellent yields （71%-96% ） and short reaction time （4-7 h）.