VEGF、MMP-2在乳腺癌中的表达及其临床意义

Expressions of MMP-2 and VEGF in the tissues of breast cancer and its clinical significance

目的:探讨血管内皮生长因子(VEGF)和基质金属蛋白酶-2(MMP-2)在乳腺癌发生、发展过程中的临床意义。方法:运用免疫组织化学二步法检测64例乳腺癌(乳腺癌组)和16例乳腺良性病变(对照组)中的VEGF、MMP-2的表达情况,并分析其与临床病理参数的关系。结果:(1)VEGF、MMP-2在乳腺癌中阳性表达率分别为78.10%(50/64)、62.50%(40/64),在乳腺良性病变中的阳性表达率分别为37.50%(6/16)、31.30%(5/16),差异有统计学意义(P<0.05)。(2)VEGF和MMP-2的表达与组织学分级和腋窝淋巴结转移呈正相关;乳腺癌组织中MMP-2和VEGF的表达呈正相关。结论:VEGF和MMP-2参与乳腺癌的发生、发展过程,可作为评估乳腺癌浸润和转移的重要生物学指标。

Objective： To study expressions of vascular endothelial growth factor （VEGF） and matrix metal loproteinase-2 （MMP-2） in the breast cancer and evaluate its significance to clinicopathology of this tumor invasion and metastasis. Methods： The immunohistochemical staining method （two-step method） was used to evaluate the expression of VEGF and MMP-2 in 64 cases of breast cancer and 16 cases of benign breast diseases and its correlations to clinicopathologic features were analyzed. Results： （1） The positive incidence of VEGF and MMP-2 expressions in 64 cases of breast cancer were 78.10% （50/64） and 62.50%（40/64） respectively,which was improved compared with the expressions in benign breast diseases were 37.50%（6/ 16） and 31.30%（5/16） （P〈0.05）. （2） The expressions of VEGFandMMP-2 were positively correlated to axillary lymph node metastasis and pathological stage, and so did between MMP-2 and VEGF expression. Conclusions： VEGF and MMP-2 were associated in breast cancer,and could serve as an important index in the aspect of invasiveness and metastasis in breast cancer.