摘要
目的:建立以高效液相色谱法测定二羟丙茶碱片中主药含量的方法。方法:色谱柱为VPODS,流动相为甲醇-水(30:70),检测波长为273nm,流速为1.0mL·min^-1,进样量为20μL。结果:二羟丙茶碱检测浓度的线性范围为8.1-81μg·mL^-1(r=0.9998);平均回收率为100.01%,RSD=0.21%。结论:本方法操作简便、准确、精密度好,可用于该制剂的质量控制。
OBJECTIVE: To establish an HPLC method for the determination of diprophylline in diprophylline tablets. METHODS: The analytical column was C18 and the mobile phase consisted of methanol-water (30-70) at a flow rate of 1.0 mL·min^-1. The detection wavelength was 273 nm and the sample size was 20 μL. RESULTS: The linear range of dipro-phylline was 8.1-81 μg·mL^-1(r=0. 9998) with an average recovery rate of 100.01% (RSD=0.21% ) . CONCLUSION: The method is simple, accurate and precise, and it can be used for the quality control of diprophylline tablets.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第7期542-543,共2页
China Pharmacy