摘要
目的:检测宫内发育迟缓(IUGR)儿脐血胰岛素样生长因子-I(IGF-I)、胰岛素样生长因子结合蛋白-3(IGFBP-3)水平,分析这些指标的变化程度与胎儿期生长的关系。方法:将86例脐血标本分为IUGR(即小于胎龄儿)组和适于胎龄儿(AGA)组。采用放射免疫分析(RIA)测定IGF-I水平,免疫放射分析(IR-MA)测定IGFBP-3水平。两组间比较用t检验,两变量之间的关系采用相关回归分析。结果:与AGA组相比,IUGR组脐血IGF-I和IGFBP-3水平显著降低(P均<0.01);IGF-I、IGFBP-3均随胎龄及出生体重增加而增加(P均<0.01);IGFBP-3与IGF-I呈正相关(P<0.01)。结论:脐血IGF-I和IGFBP-3的含量可作为判断新生儿生长发育程度的一项客观指标。
Objective To study the cord blood insulin - like growth factor - I （ IGF - I） and its bindig protein - 3 （ IGFBP - 3） levels in neonates with intrauterine growth retardation （IUGR）. Methods Cord serum IGF -I （with RIA） and IGFBP -3 （with IRMA） levels were measured in 22 neonates with IUGR and 64 neonates with appropriate gestational age （AGA）. Results Cord blood IGF - I and IGFBP - 3 levels in IUGR neonates were significantly lower than those in AGA neonates （ P 〈 0. 001 ）. Among the 85 neonates studied in this article, 44 were born pre - term and 42 were born full term. From the data, we could see that the cord blood IGF - I and IGFBP - 3 levels in pre - term neonates were significantly lower than those in full - term neonates （ P also 〈 0. 001 ）. IGF - I and IGFBP - 3 levels were mutually positively correlated （P 〈 0.01 ）. Conclusion Cord blood IGF - I and IGFBP - 3 levels were useful indicator of neonates growth.
出处
《放射免疫学杂志》
CAS
2008年第1期8-9,共2页
Journal of Radioimmanology
关键词
胰岛素样生长因子-I
胰岛素样生长因子结合蛋白-3
宫内发育迟缓
insulin - like growth factor - I, insulin - like growth factor binding protein - 3, intrauterine growth retardation
