108例冠心病患者的血脂分析和hs-CRP测定的临床应用

Clinical Application of Determination of Lipids and high-sensitivity C-reactive Protein Contents in 108 Patients with Coronary Heart Disease

目的:探讨冠心病患者血脂和超敏C-反应蛋白分析的临床意义。方法:生化法和RIA对108例冠心病患者和60例正常对照组中血清胆固醇(total cholesterol,TC)、三酰甘油(triglycerides,TC),低密度脂蛋白胆固醇(lowdensity lipoprotein cholesterol,LDL-C),高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)和超敏C-反应蛋白(high sensitivity C-reaction protein,hs-CRP)水平。结果:108例冠心病患者较之60例正常对照组血清TC、TG、LDL-C和hs-CRP显著增高(TC、TG和LDL-C之P<0.05,而hs-CRP之P<0.01),而HDL-C显著降低(P<0.05)。结论:血清TC、TG、LDL-C,HDL-C和hs-CRP与冠心病密切相关,而且这些因素是冠心病诊断的重要标志物,并能反映严重程度。

Objective To study the clinical application of determination of serum lipiols and hs - CRP contents in patients with coronary heart disease. Methods The levels of serum TC, TG, LDL-C. HDL-C （with biochemistry） and hs -CRP （with RIA） were measured in 108 patients with coronary heart disease and 60 controls. Results Serum TC, TG, LDL - C and hs - CRP levels in the patients with coronary heart disease were significantly higher （P 〈0.05 or P 〈0.01 ） but serum HDL - C was significantly lower （P 〈 0.05） in the patients than those in controls. Conclusion Serum TC, TG, LDL - C, HDL - C and hs - CRP were important markers in the diagnosis of coronary heart disease, and their levels could reflect the severity of the disease.