血浆花生四烯酸代谢指标在高血压肾病患者中的变化及意义

Clinical Significance of Changes of Plasma Concentrations of Arachidonic Acid Metabolites in Patients with Hypertensive Nephropathy

目的:探讨了血浆6-酮-前列腺素F1α(6-酮-PGF1α)、8-表氧-前列腺素F2α(8-表氧-PGF2α)和11-去氢-血栓烷B2(DH-TXB2)水平在高血压肾病中的变化及意义。方法:应用放射免疫分析测定36例高血压肾病患者血浆中6-酮-PGF1α、8-表氧-PGF2α和酶联免疫法检测11-去氢-血栓烷B2,并以35名正常健康人作比较。结果:高血压肾病组血浆8-表氧-PGF2α、DH-TXB2水平显著地高于正常人组(P<0.01),而6-酮-PGF1α水平则显著地低于正常人组(P<0.01),血浆6-酮-PGF1α与尿微量白蛋白(UAlb)水平呈负相关(r=-0.3525,P<0.05),而血浆DH-TXB2和8-表氧-PGF2α水平均与UAlb水平呈正相关(r=0.4213、0.4716,P<0.05)。结论:血管内皮受损、血小板活化和脂质过氧化是高血压肾病的发生、发展的重要机制。

Objective To investigate the clinical significance of changes of plasma 6 - Keto - Prostaglandin F1α （ 6 - Keto - PGF1α ）, 8 - epi - Prostaglandin F2α （ 8 - epi - PGF2α ） and 11 - dehydrothyomboxane B2 （ DH - TXB2 ） in patients with hypertensive nephropathy. Methods Plasma 6 - Keto - PGF1α and 8 - epi - PGF2α （ with RIA） and 11 - DH - TXB2 （ with ELISA） levels were determined in 36 patients with hypertensive nephropathy and 35 controls. Results Plasma 8 - epi - PGF2α, DH - TXB2 levels were sigvificantly higher in the patients than those in controls （ P 〈 0.01 ）, while serum 6 - Keto - PGF1α levels were significantly lower （P 〈 0.01 ）. The levels of plasma 6 - Keto - PGF1α were negatively correlated with UAIb, while the concentrations of plasma 8 - epi - PGF2α and DH - TXB2 were positively correlated with UAIb （ both P 〈 0.05）. Conclusion Endothelial cell oxidative injury stress and platelet activation might play important role in the pathogenesis of hypertension nephropathy.